PHYTOPHALE CHATS, CHIENS NAINS 32 CPR VET

Oral use.
Dosage :
15 mg dry extract of lespedeza capitata, 13.35 mg dry extract of artichoke and 8.35 mg dry extract of orthosiphon per kg body weight per day corresponding to:
1 tablet per 2 kg of body weight.

The tablet is administered orally, either by placing it directly down the throat or by putting it in a meatball.
Drinking water should be made available to the animals after administration of the tablets.

Qualitative and quantitative composition Active ingredients and excipients of note :
One 143 mg tablet contains:
- Active ingredients:
Lespedeza capitata (dry extract of) ..... 30.0 mg
Artichoke (dried extract of) ..... 26.7 mg
Orthosiphon (dried extract of) ..... 16.7 mg

Active ingredients / Molecule :
Artichoke, Orthosiphon, Lespedeza capitata
Pharmaceutical form :
Tablet

Inclusion in the table of poisonous substances (List I / II). Classification of the medicinal product for dispensing :

Veterinary medicinal product.

Withdrawal period :
Not applicable.

Properties
Pharmacodynamic properties:
- Lespedeza capitata: this plant extract is azoturic and mild diuretic and does not alter the ionic balance.

- Artichoke: the leaf extract is diuretic and choleretic. The 1,5-dicaffeylquinic acid is responsible for an increase in bile flow and induces hepatoprotection against toxins (ethanol, carbon tetrachloride, a-amanitine...). Artichoke extracts cause a modification of lipid metabolism (antiatherogenic effect) with a decrease in triglycerides and about 10 to 12% of the total cholesterol level. Finally, all the substances (flavonoids in particular) have an antioxidant power that has been demonstrated on hepatocyte cultures.

- Orthosiphon: the extract is nitrogenous and diuretic. The excretion of sodium chloride and also of K+ ions and urea is increased. Some double-blind clinical studies against placebo have confirmed the activity on diuresis. In bioassays, orthosiphols A and B have been shown to be potent antiphlogistics and the methoxylated flavones have 5-lipoxygenase inhibitory properties.

Pharmacokinetic properties :
Lespedeza capitata: good resorption from the digestive tract. Hepatic and renal metabolism. Elimination mainly renal.